Merlino is a surname of Italian origin with several meanings. It may either be from the Arthurian personal name Merlino, borrowed from French Merlin, a diminutive of Merlo, which means 'blackbird', or a habitational name from Merlino, Lombardy.

Notable people with the surname include:

Chuckie Merlino (1939–2012), American mobster Doug Merlino, American writer and journalist Francesco Saverio Merlino (1856–1930), Italian lawyer, anarchist and theorist Gabriel Merlino (born 1977), Argentine bandoneon player Gene Merlino (1928–2024), American singer and musician James Merlino (born 1972), Australian politician Joey Merlino (born 1962), American mobster Joseph P. Merlino (1922–1998), American politician Kristen Merlino, American art director Lorenzo Merlino (born 1972), Brazilian fashion designer Mario Merlino (1944–2026), Italian neo-fascist activist and historian Mauro Merlino (born 1969), Italian social and political activist Maxine Merlino (1912–2013), American illustrator, muralist and arts educator Nell Merlino, American social entrepreneur and author Tim Merlino, American politician