Isaza is a surname of Basque origins. Notable people with this surname include:
Carlos Alberto Restrepo Isaza (born 1961), Colombian-born football coach and current manager Guillermo Cano Isaza (1925–1986), Colombian journalist Gustavo Isaza Mejía (died 2007), Colombian physician, surgeon and professor Harold Isaza Gutiérrez (born 1995), Colombian professional footballer Jorge García Isaza (1928–2016), Colombian Roman Catholic bishop José Isaza (born 1972), Panamanian swimmer Kaleil Isaza Tuzman, American-born entrepreneur associated with digital media Ilean Isaza Aizpurúa (1970), Panamanian born Archaeologist and Program Manager