Matlock is a surname. Notable people with the surname include:
Bob Matlock (1918–2006), Australian rules footballer Glen Matlock (born 1956), English bass player in the original line-up for punk band the Sex Pistols Jack F. Matlock Jr. (born 1929), American diplomat Jimmy Matlock (born 1959), American politician Leroy Matlock (1907–1968), American Negro league baseball player Mark Matlock (born 1969), founder and president of WisdomWorks Ministries Matty Matlock (1907–1978), American jazz musician and arranger Michelle Matlock, American professional clown and female lead in the Cirque du Soleil production Ovo Rebecca Matlock (1928–2019), photographer and wife of former U.S. Ambassador Jack F. Matlock, Jr Ronn Matlock (1947–2020), American singer and songwriter Scott Matlock (born 2000), American football player Spider Matlock (1901–1936), American stuntman and racing mechanic Victoria Matlock (born 1978), American musical theatre actress