The Million Dollar Challenge may refer to:

The Nedbank Golf Challenge, an annual golf tournament The One Million Dollar Paranormal Challenge administered by the James Randi Educational Foundation to demonstrate psychic ability Million Dollar Challenge (TV program), an American poker television show The Thermal Club IndyCar Grand Prix, an IndyCar Series race initially called the $1 Million Challenge 2024 $1 Million Challenge, the first running of the above race, when it was known as the $1 Million Challenge