Santo is a surname. Notable people with the surname include:
Akiko Santō (born 1942), Japanese politician Anthony Santo (c. 1894–?), Italian-American murderer Audrey Santo (1983–2007), or Little Audrey, through whom miracles were said to have happened Damián de Santo (born 1968), Argentine actor Guillermo Santo (born 1982), Argentine footballer Hildi Santo-Tomas (born 1961), American interior designer and television personality Ron Santo (1940–2010), American baseball player and broadcaster