Alexander Zverev defeated Matteo Berrettini in the final, 6–7(8–10), 6–4, 6–3 to win the men's singles tennis title at the 2021 Madrid Open. It was his fourth Masters 1000 title, his first since the 2018 Madrid Open, and his 15th career ATP Tour singles title overall.
Novak Djokovic was the reigning champion from when the tournament was last held in 2019, but did not participate.
Following the third-round eliminations of Daniil Medvedev and Stefanos Tsitsipas, respectively, a first-time Masters 1000 singles finalist from the bottom half of the draw was guaranteed; Berrettini went on to become that player.
Seeds The top eight seeds received a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Qualifying
Seeds
Qualifiers
Lucky loser
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
ATP singles main-draw entrants
Seeds The following are the seeded players. Seedings are based on ATP rankings as of 26 April 2021. Rankings and points before are as of 3 May 2021. SeedRankPlayerPoints beforePoints defendingPoints wonPoints afterStatus 1 2 Rafael Nadal 9,810 360 180 9,630 Quarterfinals lost to Alexander Zverev 2 3 Daniil Medvedev 9,700 10 90 9,780 Third round lost to Cristian Garín 3 4 Dominic Thiem 8,365 360 360 8,365 Semifinals lost to Alexander Zverev 4 5 Stefanos Tsitsipas 7,910 390 90 7,610 Third round lost to Casper Ruud 5 6 Alexander Zverev 6,125 180 1,000 6,945 Champion, defeated Matteo Berrettini 6 8 Andrey Rublev 6,000 90 90 6,000 Third round lost to John Isner 7 9 Diego Schwartzman 3,765 67 45 3,743 Second round lost to Aslan Karatsev 8 10 Matteo Berrettini 3,493 45 600 4,048 Runner-up, lost to Alexander Zverev 9 11 Roberto Bautista Agut 3,090 10 45 3,125 Second round lost to John Isner 10 12 Pablo Carreño Busta 3,015 10 10 3,015 First round lost to 11 14 Denis Shapovalov 2,820 10 45 2,855 Second round lost to Alexander Bublik 12 16 Hubert Hurkacz 2,600 67 10 2,543 First round lost to John Millman 13 17 Grigor Dimitrov 2,576 10 10 2,576 First round lost to Lloyd Harris 14 18 Jannik Sinner 2,524 24 45 2,545 Second round lost to Alexei Popyrin [Q] 15 20 Félix Auger-Aliassime 2,418 32 10 2,396 First round lost to Casper Ruud 16 22 Cristian Garín 2,215 45 180 2,350 Quarterfinals lost to Matteo Berrettini
Other entrants The following players received wildcards into the main draw: Carlos Alcaraz Pedro Martínez Jaume Munar Fernando Verdasco
The following players received entry from the qualifying draw: Pablo Andújar Marco Cecchinato Federico Delbonis Marcos Giron Pierre-Hugues Herbert Alexei Popyrin Carlos Taberner
The following player received entry as a lucky loser: Yoshihito Nishioka
Withdrawals Before the tournament Marin Čilić → replaced by Tommy Paul Borna Ćorić → replaced by Jérémy Chardy Novak Djokovic → replaced by Alejandro Davidovich Fokina Roger Federer → replaced by Miomir Kecmanović David Goffin → replaced by Lloyd Harris Gaël Monfils → replaced by Guido Pella Milos Raonic → replaced by Yoshihito Nishioka Lorenzo Sonego → replaced by Dominik Koepfer Stan Wawrinka → replaced by Albert Ramos Viñolas
Retirements Lloyd Harris Guido Pella
References
External links Main draw Qualifying draw