José León or José de León may refer to:
Arts and entertainment José León Sánchez (1929–2022), Costa Rican novelist Joey de Leon (José María Ramos de León Jr., born 1946), Filipino comedian and actor
Government and politics José de León y Echales (died 1699), Spanish governor of Trinidad José León Sandoval (fl. 1845–1847), Nicaraguan president José María León Jiménez (1893–1936), Spanish politician José Antonio León Mendivil (born 1946), Mexican politician José Luis León Perea (born 1947), Mexican politician José Gaudencio León Castañeda (born 1960), Mexican politician
Sports Pepe León (José León Gómez, 1935–2026), Spanish football club chairman José Vicente León (1943–1977), Spanish swimmer José DeLeón (1960–2024), Dominican baseball pitcher José León (baseball) (born 1976), Puerto Rican baseball third baseman José De León (born 1992), Puerto Rican baseball pitcher José Reynaldo Bencosme de Leon (born 1992), Italian hurdler José León (footballer) (born 1995), Spanish football centre-back Luis Muñoz (footballer, born 1997) (José Luis Muñoz León, born 1997), Spanish footballer José de León (footballer) (born 2004), Spanish-Dominican football winger
Other José de León Toral (1900–1929), Mexican Roman Catholic extremist and assassin José León Asensio (1934–2024), Dominican businessman
See also José León de Carranza Bridge, a steel bridge in Cádiz, Spain