This is a list of signaling peptide/protein receptor modulators
Adiponectin AdipoR1 Agonists: Peptide: Adiponectin ADP-355 ADP-399; Non-peptide: AdipoRon (–)-Arctigenin Arctiin Gramine Matairesinol
Antagonists: Peptide: ADP-400
AdipoR2 Agonists: Peptide: Adiponectin ADP-355 ADP-399; Non-peptide: AdipoRon Deoxyschizandrin Parthenolide Syringing Taxifoliol
Antagonists: Peptide: ADP-400
Angiotensin See here instead.
Bradykinin Agonists: Bradykinin Kallidin
Antagonists: FR-173657 Icatibant LF22-0542
Calcitonin gene-related peptide receptor Agonists: Amylin CGRP Pramlintide
Antagonists: Atogepant BI 44370 TA CGRP (8-37) MK-3207 Olcegepant Rimegepant SB-268262 Telcagepant Ubrogepant
Antibodies: Eptinezumab Erenumab Fremanezumab Galcanezumab
Cholecystokinin CCKA Agonists: Cholecystokinin
Antagonists: Amiglumide Asperlicin Devazepide Dexloxiglumide Lintitript Lorglumide Loxiglumide Pranazepide Proglumide Tarazepide Tomoglumide
CCKB Agonists: Cholecystokinin CCK-4 Gastrin Pentagastrin (CCK-5)
Antagonists: Ceclazepide CI-988 (PD-134308) Itriglumide L-365,360 Netazepide Proglumide Spiroglumide
Unsorted Antagonists: Nastorazepide
Corticotropin-releasing hormone receptor CRF1 Agonists: Cortagine Corticorelin Corticotropin-releasing hormone Sauvagine Stressin I Urocortin
Antagonists: Antalarmin Astressin-B CP-154,526 Emicerfont Hypericin LWH-234 NBI-27914 NBI-74788 Pexacerfont R-121919 TS-041 Verucerfont
CRF2 Agonists: Corticorelin Corticotropin-releasing hormone Sauvagine Urocortin
Antagonists: Astressin-B
Cytokine See here instead.
Endothelin Agonists: Endothelin 1 Endothelin 2 Endothelin 3 IRL-1620 Sarafotoxin
Antagonists: A-192621 Ambrisentan Aprocitentan Atrasentan Avosentan Bosentan BQ-123 BQ-788 Clazosentan Darusentan Edonentan Enrasentan Fandosentan Feloprentan Macitentan Nebentan Sitaxentan Sparsentan Tezosentan Zibotentan
Galanin GAL1 Agonists: Galanin Galanin (1-15) Galanin-like peptide Galmic Galnon NAX 810-2
Antagonists: C7 Dithiepine-1,1,4,4-tetroxide Galantide (M15) M32 M35 M40 SCH-202596
GAL2 Agonists: Galanin Galanin (1-15) Galanin (2-11) Galanin-like peptide Galmic Galnon J18 NAX 810-2
Antagonists: C7 Galantide (M15) M32 M35 M40 M871
GAL3 Agonists: Galanin Galanin (1-15) Galmic Galnon
Antagonists: C7 Galantide (M15) GalR3ant HT-2157 M32 M35 M40 SNAP-37889 SNAP-398299
Ghrelin/GHS See here instead.
GH See here instead.
GHRH See here instead.
GLP GLP-1 Agonists: Albiglutide Beinaglutide Dulaglutide Efpeglenatide Exenatide GLP-1 Langlenatide Liraglutide Lixisenatide Oxyntomodulin Pegapamodutide Semaglutide Taspoglutide
GLP-2 Agonists: Apraglutide Elsiglutide Glepaglutide GLP-2 Teduglutide
Others Propeptides: Preproglucagon Proglucagon
Glucagon Agonists: Dasiglucagon Glucagon Oxyntomodulin
Antagonists: Adomeglivant L-168,049 LGD-6972
Propeptides: Preproglucagon Proglucagon
GnRH See here instead.
Gonadotropin See here instead.
Growth factor See here instead.
Insulin Agonists: Chaetochromin (4548-G05) Insulin-like growth factor 1 Insulin-like growth factor 2 Insulin Insulin aspart Insulin degludec Insulin detemir Insulin glargine Insulin glulisine Insulin lispro Mecasermin Mecasermin rinfabate
Antagonists: BMS-754807 S661 S961
Kinase inhibitors: Linsitinib
Antibodies: Xentuzumab (against IGF-1 and IGF-2)
Kisspeptin Agonists: Kisspeptin Kisspeptin-10
Antagonists: Kisspeptin-234
Leptin Agonists: Leptin Metreleptin
Melanin-concentrating hormone receptor MCH1 Agonists: Melanin-concentrating hormone
Antagonists: ATC-0065 ATC-0175 GW-803430 NGD-4715 SNAP-7941 SNAP-94847
MCH2 Agonists: Melanin-concentrating hormone
Melanocortin See here instead.
mTOR Activators: beta-Hydroxy beta-methylbutyric acid Hydroxynorketamine Leucine NV-5138
Inhibitors: Rapalogs: Everolimus Ridaforolimus Sirolimus (Rapamycin) Temsirolimus Umirolimus Zotarolimus; ATP-competitive / indirect: Berberine Curcumin Dactolisib EF-24 Epigallocatechin gallate HY-124798 NV-5440 Pterostilbene Quercetin Resveratrol Sapanisertib Torin-1 WYE-687 XL-388
Neuropeptide FF Agonists: Neuropeptide AF Neuropeptide FF Neuropeptide SF (RFRP-1) Neuropeptide VF (RFRP-3)
Antagonists: BIBP-3226 RF9
Neuropeptide S Agonists: Neuropeptide S
Antagonists: ML-154 SHA-68
Neuropeptide Y Y1 Agonists: Neuropeptide Y Peptide YY
Antagonists: BIBO-3304 BIBP-3226 BVD-10 GR-231118 PD-160170
Y2 Agonists: 2-Thiouridine 5'-triphosphate Neuropeptide Y Neuropeptide Y (13-36) Peptide YY Peptide YY (3-36)
Antagonists: BIIE-0246 JNJ-5207787 SF-11
Y4 Agonists: GR-231118 Neuropeptide Y Pancreatic polypeptide Peptide YY
Antagonists: UR-AK49
Y5 Agonists: BWX-46 Neuropeptide Y Peptide YY
Antagonists: CGP-71683 FMS-586 L-152,804 Lu AA-33810 MK-0557 NTNCB Velneperit (S-2367)
Neurotensin NTS1 Agonists: Neurotensin Neuromedin N Antagonists: Meclinertant SR-142948
NTS2 Agonists: Neurotensin Antagonists: Levocabastine SR-142948
Opioid See here instead.
Orexin OX1 Agonists: Orexin (A, B)
Antagonists: ACT-335827 ACT-462206 Almorexant Filorexant Lemborexant Nemorexant RTIOX-276 SB-334867 SB-408124 SB-649868 Suvorexant TCS-1102
OX2 Agonists: Orexin (A, B) SB-668875
Antagonists: ACT-335827 ACT-462206 Almorexant EMPA Filorexant JNJ-10397049 Lemborexant MK-1064 SB-649868 Seltorexant Suvorexant TCS-1102 TCS-OX2-29
Oxytocin See here instead.
Prolactin Agonists: Growth hormone Human placental lactogen Placental growth hormone (growth hormone variant) Prolactin S179D-hPRL Somatotropin
Antagonists: Δ1–9-G129R-hPRL Δ1–14-G129R-hPRL G120K-hGH G129R-hPRL
Prolactin modulators: Prolactin inhibitors: D2 receptor agonists (e.g., bromocriptine, cabergoline); Prolactin releasers: D2 receptor antagonists (e.g., domperidone, metoclopramide, risperidone) Estrogens (e.g., estradiol) Progestogens (e.g., progesterone)
PTH Agonists: Abaloparatide Parathyroid hormone Parathyroid hormone-related protein (PTHrP) Semparatide Teriparatide
Relaxin Agonists: Insulin-like factor 3 Relaxin (1, 2, 3) Serelaxin
Somatostatin See here instead.
Tachykinin See here instead.
TRH Agonists: Azetirelin Fertirelin Montirelin Orotirelin Posatirelin Protirelin Rovatirelin Taltirelin TRH (TRF)
TSH Agonists: Thyrotropin alfa TSH (thyrotropin)
Vasopressin See here instead.
VIP/PACAP VIPR1 Agonists: Peptide: Bay 55-9837 LBT-3393 PACAP VIP
VIPR2 Agonists: Peptide: LBT-3627 PACAP VIP
PAC1 Agonists: PACAP PACAP (1-27) PACAP (1-38)
Antagonists: PACAP (6-38)
Unsorted PHI PHM PHV
Others Endogenous: Adrenomedullin Apelin Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl peptide GALP GIP GRP Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) Kininogens Motilin Natriuretic peptides (ANP, BNP, CNP, urodilatin) Nesfatin-1 Neuromedin B Neuromedin N Neuromedin S Neuromedin U Obestatin Osteocalcin Resistin Secretin Thymopoietin Thymosins Thymulin Urotensin-II VGF
Exogenous: Lifitegrast (LFA-1 antagonist)
References