Lorenzo Sonego defeated defending champion Laslo Đere in the final, 2–6, 7–6(7–5), 6–4 to win the men's singles title at the 2021 Sardegna Open. With the victory, Sonego became the first Italian in 15 years to capture an ATP Tour title on home soil.

Seeds The top four seeds received a bye into the second round.

Draw

Finals

Top half

Bottom half

Qualifying

Seeds

Qualifiers

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

References

External links Main draw Qualifying draw