Veronika Kudermetova defeated Danka Kovinić in the final, 6–4, 6–2, to win the singles tennis title at the 2021 Charleston Open. Kudermetova did not drop a set en route to her first career Women's Tennis Association (WTA) singles title.
Madison Keys was the defending champion, but she lost in the second round to Sloane Stephens in a rematch of the previous tournament's quarterfinal. As all losing quarterfinalists were previous WTA title holders, all four semifinalists were in contention to become a maiden WTA champion.
Seeds The top eight seeds received a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Qualifying
Seeds
Qualifiers
Lucky losers
Draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
Eighth qualifier
References
External links Main draw Qualifying draw