Unseeded Leylah Fernandez defeated Viktorija Golubic in the final, 6–1, 6–4 to win the singles tennis title at the 2021 Monterrey Open. Fernandez did not drop a set en route to her first WTA Tour singles title.

Elina Svitolina was the reigning champion, but decided not to participate.

Seeds

Draw

Finals

Top half

Bottom half

Qualifying

Seeds

Qualifiers

Lucky losers

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

Fifth qualifier

Sixth qualifier

References

External links Main draw Qualifying draw