The 2021 Challenger de Santiago was a professional tennis tournament played on clay courts. It was the 13th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 15 and 21 March 2021.
Singles main-draw entrants Seeds Country Player Rank1 SeedRoberto Carballés Baena971Andrej Martin1042Pedro Sousa1103Facundo Bagnis1184Jozef Kovalík1295Daniel Altmaier1436Kimmer Coppejans1657Alejandro Tabilo1688 1 Rankings are as of 8 March 2021.
Other entrants The following players received wildcards into the singles main draw: Nicolás Jarry Gonzalo Lama Holger Rune
The following player received entry into the singles main draw as an alternate: Camilo Ugo Carabelli
The following players received entry from the qualifying draw: Martín Cuevas Nicolás Kicker João Menezes Gonzalo Villanueva
The following player received entry as a lucky loser: Rafael Matos
Champions Singles
Sebastián Báez def. Marcelo Tomás Barrios Vera 6–3, 7–6(7–4).
Doubles
Luis David Martínez / Gonçalo Oliveira def. Rafael Matos / Felipe Meligeni Alves 7–5, 6–1.
References