Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.
Thiago Seyboth Wild was the defending champion, but chose not to defend his title.
Seeds The top four seeds received a bye into the second round.
Draw
Finals
Top half
Bottom half
Qualifying
Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw