Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Casper Ruud was the defending champion, but chose not to participate.
Seeds The top four seeds receive a bye into the second round.
Draw
Finals
Top half
Bottom half
Qualifying
Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw