In music, Op. 80 stands for Opus number 80. Compositions that are assigned this number include:

Beethoven – Choral Fantasy (Beethoven) Brahms – Academic Festival Overture Dvořák – String Quartet No. 8 Elgar – The Spirit of England Fauré – Pelléas et Mélisande Mendelssohn – String Quartet No. 6 Prokofiev – Violin Sonata No. 1 Reger – Zwölf Stücke, Op. 80 Schumann – Piano Trio No. 2 Sibelius – Violin Sonatina in E major, duo for violin and piano (1915) Strauss – Die schweigsame Frau