Dan Evans defeated Félix Auger-Aliassime in the final, 6–2, 6–3 to win the inaugural singles tennis title at the 2021 Murray River Open. It was his first ATP Tour title. The final marked Auger-Aliassime's seventh career runner-up finish from seven ATP Tour finals appearances.
Seeds The top eight seeds received a bye into the second round.
Stan Wawrinka (quarterfinals, withdrew) Grigor Dimitrov (quarterfinals) Félix Auger-Aliassime (final) Borna Ćorić (quarterfinals) Casper Ruud (second round) Taylor Fritz (third round) Ugo Humbert (second round) Dan Evans (champion)
Lorenzo Sonego (first round) Adrian Mannarino (second round) Marin Čilić (first round) Albert Ramos Viñolas (second round) Nick Kyrgios (third round) Richard Gasquet (first round) Tommy Paul (second round) Márton Fucsovics (second round)
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
References
Main draw