Brendan O'Brien may refer to:
Brendan O'Brien (bishop) (born 1943), Roman Catholic archbishop of Kingston, Ontario, Canada Brendan O'Brien (cricketer) (born 1942), Irish former cricketer Brendan O'Brien (journalist) (1943/1944–2026), Irish journalist on RTÉ's Prime Time current affairs programme Brendan O'Brien (record producer) (born 1960), record producer, mixer, engineer, and musician Brendan O'Brien (screenwriter), American screenwriter Brendan O'Brien (actor) (1962–2023), actor and voice of many Crash Bandicoot characters