Samuel Spencer may refer to:
Samuel Spencer (North Carolina politician) (1734–1794), North Carolina judge, lawyer, and Revolutionary War colonel Samuel M. Spencer (1875–1960), politician on Hawaii island Samuel R. Spencer (1871–1961), American politician, lieutenant governor of Connecticut Samuel Spencer (railroad executive) (1847–1906), first president of the Southern Railway S. B. Spencer (1827–1901), mayor of Atlanta, Georgia Sam Spencer (1902–1987), English footballer Samuel Reid Spencer Jr. (1919–2013), president of Davidson College Samuel A. Spencer, American politician in the Virginia House of Delegates Samuel Spencer (DC commissioner) (1910–1997), president of the District of Columbia Board of Commissioners