Di Francesco (or di Francesco) is an Italian surname. Notable people with this surname include:
Dario DiFrancesco (born 1948), Italian physiologist David DiFrancesco (born 1949), American photo scientist, inventor, cinematographer and photographer Donald DiFrancesco (born 1944), American politician Eusebio Di Francesco (born 1969), Italian football player and manager Federico Di Francesco (born 1994), Italian footballer Gianmarco Di Francesco (born 1989), Italian cyclist Giovanni di Francesco (1412–1459), Italian painter Lupo di Francesco ( 14th century), Italian sculptor and architect Mauro Di Francesco (1951–2025), Italian actor, comedian and television personality Philippe Di Francesco, French-American mathematician Stefano di Francesco (died 1427), Italian painter
See also Francesco De Francesco