6-Chloronicotine is a drug which acts as an agonist at nicotinic acetylcholine receptors. It substitutes for nicotine in animal studies with around twice the potency, and shows antinociceptive effects. Pharmacology The antinociceptive effects of 6-chloronicotine are reported to be some 15.4 times the relative potency of nicotine in the tail flick test. 6-Bromonicotine was 14.4 times nicotine in this same test.
Application 6-Chloronicotine is used in the synthesis of macrostomine (c.f. ).
Another application is in the synthesis of brevicolline, a naturally occurring harmala alkaloid present in Carex brevicollis.
See also 5-Iodo-A-85380 6-Methylnicotine ABT-418 Altinicline Epibatidine Tebanicline
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