The 2021 NCAA Division I baseball tournament was the 74th edition of the NCAA Division I Baseball Championship. The 64-team tournament began on Friday, June 4, 2021, as part of the 2021 NCAA Division I baseball season and concluded with the 2021 College World Series in Omaha, Nebraska, which started on June 19 and ended on June 30. Mississippi State defeated Vanderbilt in the best-of-three final series to win their first national championship in program history.

The 64 participating NCAA Division I college baseball teams were selected out of an eligible 299 teams. There were 30 teams awarded an automatic bid as champions of their conferences, and 34 teams were selected at-large by the NCAA Division I Baseball Committee. Teams were divided into sixteen regionals of four teams, each of which conducted a double-elimination tournament. Regional champions then faced each other in Super Regionals, a best-of-three game series, to determine the eight participants in the College World Series.

Grand Canyon, NJIT, Norfolk State and Presbyterian made their NCAA tournament debuts after winning their first conference tournaments in program history. Nevada qualified for the tournament for the first time since 2000, Rider qualified for the first time since 2010 and Charlotte qualified for the first time since 2011. Auburn and Louisville were the lone teams from the 2019 College World Series field to fail to qualify.

Tournament procedure A total of 64 teams entered the tournament, with 30 of them (down from 31, due to the Ivy League having cancelled all spring sports due to COVID-19) receiving an automatic bid by winning their conference's tournament. The remaining 34 bids were at-large", with selections extended by the NCAA Selection Committee.

On Friday, May 14, the NCAA Selection Committee announced 20 potential sites for the first round regionals due to necessary coronavirus precautions, which were reduced to 16 on May 30. Typically, the top sixteen teams receive national seeds and host their respective regional tournaments. However, since the committee determined only twenty potential sites, if a team outside that list of twenty were to receive a national seed, they would play their regional on the road. This had not occurred since 2010 when No. 1 seed Florida State Seminoles traveled to the Norwich Regional hosted by UConn at Dodd Memorial Stadium. Despite receiving a national seed, Old Dominion travelled to Founders Park at the Columbia Regional hosted by the University of South Carolina.

Schedule and venues On May 30, the NCAA Division I Baseball Committee announced the sixteen regional host sites. The Southeastern Conference led the way with seven hosts. The Big 12 Conference and Pac-12 Conference each had three regional hosts, while Conference USA, Atlantic Coast Conference, and American Athletic Conference each had one regional host. Texas led all institutions as they hosted for the 28th time. Louisiana Tech hosted for the first time in program history.

The Super Regional sites were announced on the morning of Tuesday, June 8, after the completion of the regional round.

Regionals June 4–7 UFCU Disch–Falk Field, Austin, Texas, (Host: University of Texas at Austin) Founders Park, Columbia, South Carolina, (Host: University of South Carolina) PK Park, Eugene, Oregon (Host: University of Oregon) Baum–Walker Stadium, Fayetteville, Arkansas (Host: University of Arkansas) Lupton Stadium, Fort Worth, Texas, (Host: Texas Christian University) Florida Ballpark, Gainesville, Florida, (Host: University of Florida) Clark–LeClair Stadium, Greenville, North Carolina, (Host: East Carolina University) Lindsey Nelson Stadium, Knoxville, Tennessee, (Host: University of Tennessee) Dan Law Field at Rip Griffin Park, Lubbock, Texas, (Host: Texas Tech University) Hawkins Field, Nashville, Tennessee, (Host: Vanderbilt University) Swayze Field, Oxford, Mississippi, (Host: University of Mississippi) J. C. Love Field at Pat Patterson Park, Ruston, Louisiana, (Host: Louisiana Tech University) Frank Eck Stadium, South Bend, Indiana (Host: University of Notre Dame) Klein Field at Sunken Diamond, Stanford, California (Host: Stanford University) Dudy Noble Field, Polk–DeMent Stadium, Starkville, Mississippi, (Host: Mississippi State University) Hi Corbett Field, Tucson, Arizona (Host: University of Arizona)

Super Regionals June 11–13 Baum–Walker Stadium, Fayetteville, Arkansas (Host: University of Arkansas) Dan Law Field at Rip Griffin Park, Lubbock, Texas (Host: Texas Tech University) Hi Corbett Field, Tucson, Arizona (Host: University of Arizona) Hawkins Field, Nashville, Tennessee (Host: Vanderbilt University) June 12–14 UFCU Disch–Falk Field, Austin, Texas (Host: University of Texas at Austin) Dudy Noble Field, Polk–DeMent Stadium, Starkville, Mississippi (Host: Mississippi State University) Founders Park, Columbia, South Carolina (Host: University of South Carolina) Lindsey Nelson Stadium, Knoxville, Tennessee (Host: University of Tennessee)

College World Series June 19–30 TD Ameritrade Park Omaha, Omaha, Nebraska, (Host: Creighton University)

Bids Of the 64 qualified to play in the 2021 NCAA Division I baseball tournament, 35 competed in the previous tournament in 2019. Grand Canyon, NJIT, Norfolk State and Presbyterian all made their NCAA tournament debuts after winning their first conference tournaments in program history. Nevada qualified for the tournament for the first time since 2000, Rider qualified for the first time since 2010 and Charlotte qualified for the first time since 2011.

Notable teams that failed to qualify included Auburn and Louisville, who both advanced to the 2019 College World Series.

School Conference Record (Conf) Berth Last NCAA Appearance Alabama SEC 31–24 (12–17) At-large 2014 (Tallahassee Regional) Arizona Pac-12 40–15 (21–9) Regular season 2017 (Lubbock Regional) Arizona State Pac-12 32–20 (16–14) At-large 2019 (Baton Rouge Regional) Arkansas SEC 46–10 (22–8) Tournament 2019 College World Series Patriot 28–23 (15–10) Tournament 2019 (Lubbock Regional) Campbell Big South 35–16 (28–9) At-large 2019 (Greenville Regional) Northeast 28–13 (21–9) Tournament 2019 (Fayetteville Regional) Mid-American 40–16 (31–9) Regular season 2019 (Starkville Regional) Charlotte Conference USA 39–19 (24–8) At-large 2011 (Tempe Regional) Dallas Baptist Missouri Valley 37–15 (18–6) Tournament 2019 (Lubbock Regional) Duke ACC 32–20 (16–17) Tournament 2019 (Morgantown Regional) East Carolina American 41–15 (20–8) At-large 2019 (Louisville Super Regional) Fairfield Metro Atlantic 37–3 (33–1) At-large 2016 (Lubbock Regional) Florida SEC 38–20 (17–13) At-large 2019 (Lubbock Regional) Florida State ACC 30–22 (20–16) At-large 2019 College World Series Georgia Tech ACC 29–23 (21–15) At-large 2019 (Atlanta Regional) West Coast 33–17 (20–7) Regular season 2018 (Minneapolis Regional) Western Athletic 39–19–1 (29–7) Tournament First appearance Missouri Valley 30–19 (14–10) At-large 2019 (Nashville Regional) Jacksonville ASUN 16–32 (4–15) Tournament 2018 (Gainesville Regional) Liberty ASUN 39–14 (19–2) At-large 2019 (Chapel Hill Regional) Louisiana Tech Conference USA 40–18 (22–8) At-large 2016 (Starkville Regional) LSU SEC 34–22 (13–17) At-large 2019 (Baton Rouge Super Regional) Maryland Big Ten 28–16 (28–16) At-large 2017 (Winston-Salem Regional) McNeese State Southland 32–28 (21–18) Tournament 2019 (Nashville Regional) Miami (FL) ACC 32–19 (20–15) At-large 2019 (Starkville Regional) Michigan Big Ten 27–17 (27–17) At-large 2019 College World Series Runner-up Mississippi State SEC 40–15 (20–10) At-large 2019 College World Series NC State ACC 30–17 (19–14) At-large 2019 (Greenville Regional) Nebraska Big Ten 31–12 (31–12) Regular season 2019 (Oklahoma City Regional) Mountain West 25–18 (22–9) Regular season 2000 (Palo Alto Regional) America East 26–22 (23–17) Tournament First appearance Norfolk State Mid-Eastern 25–26 (18–10) Tournament First appearance North Carolina ACC 27–25 (18–18) At-large 2019 (Chapel Hill Super Regional) North Dakota State Summit 41–17 (20–11) Tournament 2014 (Corvallis Regional) Colonial 36–10 (20–3) Tournament 2018 (Raleigh Regional) Notre Dame ACC 30–11 (25–10) At-large 2015 (Champaign Regional) Oklahoma State Big 12 35–17–1 (12–12) At-large 2019 (Lubbock Super Regional) Old Dominion Conference USA 42–14 (22–10) Tournament 2014 (Columbia Regional) Ole Miss SEC 41–19 (18–12) At-large 2019 (Fayetteville Super Regional) Pac-12 37–14 (20–10) At-large 2015 (Springfield Regional) Oregon State Pac-12 34–22 (16–14) At-large 2019 (Corvallis Regional) Big South 22–21 (18–16) Tournament First appearance Metro Atlantic 23–16 (18–16) Tournament 2010 (Austin Regional) Samford Southern 35–22 (20–10) Tournament 2018 (Tallahassee Regional) South Alabama Sun Belt 33–20 (15–9) Tournament 2017 (Hattiesburg Regional) South Carolina SEC 33–21 (16–14) At-large 2018 (Fayetteville Super Regional) American 28–27 (14–14) Tournament 2018 (DeLand Regional) Ohio Valley 30–20 (17–10) Tournament 2016 (Starkville Regional) Southern Southwestern Athletic 20–28 (13–11) Tournament 2019 (Starkville Regional) Southern Miss Conference USA 37–19 (22–9) At-large 2019 (Baton Rouge Regional) Stanford Pac-12 33–14 (17–10) At-large 2019 (Starkville Super Regional) TCU Big 12 40–17 (17–7) Tournament 2019 (Fayetteville Regional) Tennessee SEC 45–16 (20–10) At-large 2019 (Chapel Hill Regional) Texas Big 12 42–15 (17–7) At-large 2018 College World Series Texas Tech Big 12 36–15 (14–10) At-large 2019 College World Series UC Irvine Big West 40–16 (32–8) Regular season 2014 College World Series UC Santa Barbara Big West 39–18 (29–11) At-large 2019 (Stanford Regional) UCLA Pac-12 35–18 (18–12) At-large 2019 (Los Angeles Super Regional) UConn Big East 33–16 (13–4) Tournament 2019 (Oklahoma City Regional) Vanderbilt SEC 40–15 (19–10) At-large 2019 National champions VCU Atlantic 10 37–14 (13–3) Tournament 2015 (Dallas Regional) Virginia ACC 29–23 (18–18) At-large 2017 (Fort Worth Regional) Wright State Horizon 35–11 (28–4) Tournament 2018 (Stanford Regional)

By conference Conference Total Schools SEC9 Alabama, Arkansas, Florida, LSU, Mississippi State, Ole Miss, South Carolina, Tennessee, Vanderbilt ACC8 Duke, Florida State, Georgia Tech, Miami, NC State, North Carolina, Notre Dame, Virginia Pac-126 Arizona, Arizona State, , Oregon State, Stanford, UCLA Big 124 TCU, Texas, Texas Tech, Oklahoma State 4 Charlotte, Louisiana Tech, Old Dominion, Southern Miss Big Ten3 Maryland, Michigan, Nebraska American2 East Carolina, ASUN2 Liberty, Jacksonville Big South2 Campbell, Big West2 UC Irvine, UC Santa Barbara Metro Atlantic2 Fairfield, Missouri Valley2 Dallas Baptist, America East1 Atlantic 101 VCU Big East1 UConn Colonial1 Horizon1 Wright State Mid-American1 Mid-Eastern1 Norfolk State Mountain West1 Northeast1 Ohio Valley1 Patriot1 Southern1 Samford Southland1 McNeese State Southwestern Athletic1 Southern Summit1 North Dakota State Sun Belt1 South Alabama West Coast1 Western Athletic1

National seeds The sixteen national seeds were announced on the Selection Show on Monday, May 31 at 12 p.m. EDT on ESPN2. Teams in italics advanced to the Super Regionals. Teams in bold advanced to the 2021 College World Series.

Arkansas Texas Tennessee Vanderbilt Arizona TCU Mississippi State Texas Tech Stanford Notre Dame Old Dominion Ole Miss East Carolina

Florida Louisiana Tech

Regionals and Super Regionals

Bold indicates winner. Seeds for regional tournaments indicate seeds within regional. Seeds for super regional tournaments indicate national seeds only.

Fayetteville Super Regional

Lubbock Super Regional

Tucson Super Regional

Nashville Super Regional

Knoxville Super Regional

Columbia Super Regional