Ed O'Keefe (born 1983) is an American political correspondent.
Edward, Eddie or Ed O'Keefe may also refer to:
Ed O'Keefe (footballer) (1913–1986), Australian rules half-back Edward O'Keefe (born 1978), American presidential librarian Eddie O'Keefe (born 1988), American director of Shangri-La Suite
See also Edward O'Keeffe (born 1942), Irish politician a/k/a Ned O'Keeffe