De Dominicis is an Italian surname. Spellings include De Dominicis, de Dominicis, and DeDominicis. Notable people with the surname include:

Domenico de Dominicis (died 1478), Italian bishop Gino De Dominicis (1947–1998), Italian artist Luca De Dominicis (born 1973), Italian actor

See also Dominici (surname)