Misinformation related to the COVID-19 pandemic has been propagated by various public figures, including officials of the United States government. The Trump administration in particular made a large number of misleading statements about the pandemic. A Cornell University study found that then-president Donald Trump was "likely the largest driver" of the COVID-19 misinformation infodemic in English-language media.(Study) Trump downplayed the virus and promoted unapproved drugs. Other officials were accused of spreading misinformation, including then-U.S. Secretary of State Mike Pompeo, backing conspiracy theories regarding the origin of the virus, several U.S. senators, and then-New York City mayor Bill de Blasio, who downplayed the virus.

The United States Department of Defense conducted a clandestine social media operation to spread disinformation about Chinese COVID-19 vaccines in Southeast Asia, Central Asia, and the Middle East. This operation was initiated under the Trump administration in early 2020 and discontinued by the Biden administration in early 2021.

Trump administration

Then-president Donald Trump and his then-top economic adviser Larry Kudlow have been accused of spreading misinformation about the coronavirus. On February 25, 2020, Trump said, "I think that whole situation will start working out. We're very close to a vaccine." At the time, SARS-CoV-2 had been spreading in the United States undetected for weeks, and development of a vaccine against the virus was predicted to require a minimum of one year. In an interview with Sean Hannity on March 4, Trump also claimed that the death rate published by the World Health Organization was false and that the correct fatality rate was less than 1percent. He said, "Well, I think the 3.4 percent is really a false number — and this is just my hunch — but based on a lot of conversations with a lot of people that do this, because a lot of people will have this and it's very mild, they'll get better very rapidly. They don't even see a doctor. They don't even call a doctor. You never hear about those people", that the potential impact of the outbreak was exaggerated by Democrats plotting against him, and that it was safe for infected individuals to go to work. In a later tweet, Trump denied having made claims regarding infected individuals going to work, contrary to footage from the interview. The White House accused media of intentionally stoking fears of the virus to destabilize the administration. The Stat News reported that "President Trump and members of his administration have also said that U.S. containment of the virus is 'close to airtight' and that the virus is only as deadly as seasonal influenza. Their statements range from false to unproven, and in some cases, underestimate the challenges that public health officials must contend with in responding to the virus." Around the same time the "airtight" claim was made, SARS-CoV-2 was already past containment; the first case of community spread of the virus had been confirmed, and it was spreading faster than SARS-CoV-1, the virus responsible for the 2002–2004 SARS outbreak, with a case fatality rate at least seven times the rate for seasonal flu. Trump repeatedly compared COVID-19 to influenza, despite the fact that COVID-19's mortality rate was estimated to be approximately ten times higher. On February 26, he stated, "This is a flu. This is like a flu." On March 9, Trump compared the 546 known US cases of COVID-19 at the time and the 22 known deaths at the time to the tens of thousands of U.S. deaths from flu each year. On March 24, Trump argued that: "We lose thousands and thousands of people a year to the flu... But we've never closed down the country for the flu." On March 27, he stated: "You can call it a flu". On March 31, Trump changed his stance: "It's not the flu... It's vicious... I knew everything. I knew it could be horrible, and I knew it could be maybe good."

March 2020 On March 4, Trump blamed the Barack Obama administration for making "a decision" that delayed COVID-19 testing by the Trump administration. The policy in question had never been modified by the Obama administration, despite plans to do so. The policy's overall legal roots date to 2004, before the Obama administration. Under the umbrella of Emergency Use Authorizations, the old policy stated that laboratory-developed tests "should not be used for clinical diagnoses without FDA's approval, clearance, or authorization during an emergency declaration". However, this policy was historically treated as a recommendation and generally unenforced, with no clear legal authority of the FDA in this area. The Trump administration continued to require laboratories to apply to the FDA for approval, but allowed the laboratories to test while the FDA processed the applications.

On March 6, Trump over-promised on the availability of COVID-19 testing in the United States, claiming that "anybody that wants a test can get a test." Firstly, there were criteria needed to qualify for a test; recommendations were needed from doctors or health officials to approve testing. Secondly, the lack of test supplies resulted in some being denied tests even though doctors wanted to test them.

On March 19, Trump falsely claimed the drug chloroquine was approved by the Food and Drug Administration as a treatment for COVID-19. This led the FDA to say it had not approved any drugs or therapies for COVID-19, and strongly advised people against taking it outside of a hospital or clinical trial, due to possibly fatal side effects. While Trump claimed that "we're going to be able to make that drug available almost immediately", the leader of the FDA said the drug would still need to be tested in a "large, pragmatic clinical trial" on subjects infected with COVID-19. While Trump promoted chloroquine as a potential "game changer", Fauci said positive results thus far were still based on anecdotal evidence and not "definitive" evidence from clinical trials. At a later press briefing, Trump prevented Fauci from answering a question about the medical evidence of the effectiveness of hydroxychloroquine. Trump also remarked that re-purposing existing drugs for COVID-19 is "safe" and "not killing people", however most drugs may cause side effects. Chloroquine and its derivative hydroxychloroquine are FDA-approved to treat certain parasitic infections (e.g. malaria) and auto-immune diseases such as lupus and arthritis. Potentially serious side effects from chloroquine or hydroxychloroquine include irregular heartbeats, tinnitus, blurred vision, muscle weakness or "mental changes". Overdoses of these drugs have been documented in scientific literature, including fatal overdoses. Demand for chloroquine in Lagos, Nigeria sharply increased after Trump's comments, with three people overdosing by March 23. An Arizona engineer in his 60s died after ingesting a fish tank cleaner containing chloroquine phosphate in a vitamin cocktail prepared by his wife. The wife stated she intended to medicate her husband against the coronavirus after hearing Trump tout the potential benefits of chloroquine during a public briefing.

On March 21, Trump addressed a shortage of ventilator supply in the United States, claiming that carmaker companies General Motors (GM) and Ford "are making them right now" when the companies were not producing ventilators at the time, and had yet to change their factories' production abilities.

On March 30, Trump claimed his administration "inherited a broken test" for COVID-19. "That wasn't from us. That's been there a long time," he said. The claim was illogical because no previous administration could have prepared a test for a disease which had yet to emerge. COVID-19 emerged during Trump's presidency, having first been reported on December 31, 2019. The test was designed in 2020 by the Centers for Disease Control under the Trump administration. Trump continued to make the false claim on April 19.

April 2020

From April 2 to 9, the White House was in a standoff with CNN, which frequently declined to air the daily coronavirus Task Force briefings, and which fact-checked Trump's remarks. The White House said that if CNN did not begin airing the part of the briefing that featured the Task Force members, including Mike Pence, then the White House would disallow national health experts (including Anthony Fauci and Deborah Birx) from appearing on CNN. Pence relented and allowed Robert R. Redfield to appear on CNN.

On April 13, Donald Trump played a video at a White House briefing that defended his handling of his pandemic; the video was described as propaganda.

During an April 15 White House news conference, Trump said the US government is trying to determine if the COVID-19 virus emanated from the Wuhan Institute of Virology. The vice director of the Wuhan Institute of Virology called the accusations a "conspiracy theory".

On April 23, after a Homeland Security official stated that certain disinfectants can kill the coronavirus on surfaces, Trump openly wondered if disinfectants could be used on humans "by injection", saying "it'd be interesting to check" if that was a potential treatment. Injecting disinfectants into the body is dangerous and potentially lethal. Trump also suggested another "interesting" method to be tested: "we hit the body with a tremendous—whether it's ultraviolet or just very powerful light... supposing you brought the light inside of the body, which you can do either through the skin or in some other way." He asked coronavirus response coordinator Deborah Birx if heat or light can be used as a treatment, to which Birx stated she had not seen any treatments using heat or light. Trump attributed these ideas to him being "a person that has a good you-know-what".

The next day, the White House accused the media of taking Trump's words "out of context". In 2024, a New York Times fact-check determined Trump «did not instruct people to inject bleach, but suggested that doing so with a disinfectant was an "interesting" concept to test out». Trump said he had spoken in a "very sarcastic" manner and that he had addressed his comment "to reporters... just to see what would happen", this despite the video showing he had addressed not reporters but rather Deborah Birx directly, and had also been looking at Bill Bryan, head of the DHS science and technology division. In his defense, Trump also tried revising his comment to say disinfectant "would kill [the virus] on the hands, and that would make things much better." Disinfectants are useful for destroying microorganisms on inert surfaces, not on living tissue, and applying disinfectants on skin has the potential to cause irritation or chemical burns. After the president's remarks, the United States Environmental Protection Agency, the makers of Lysol, the World Health Organization, and other government officials issued various advisories pointing out that it is already known to be harmful to use disinfectants or ultraviolet radiation on human bodies instead of inanimate surfaces, and Birx explained that these were not under investigation as possible treatments.