Marfo is a Ghanaian surname. Notable people with this surname include:
Clement Marfo & The Frontline Darryl Marfo (born 1990), Scottish rugby player Edward Oppong Marfo, Ghanaian journalist Emmanuel Marfo, Ghanaian politician Kevin Marfo (born 1997), American basketball player Nana Amaniampong Marfo (born 1957), Ghanaian politician Rex Owusu Marfo, also known as Rex Omar, Ghanaian artist