Handique is a surname. Notable people with the surname include:
Aideu Handique (1920–2002), Indian actress Bijoy Krishna Handique (1934–2015), Indian politician Krishna Kanta Handique (1898–1982), Indian Sanskrit scholar. Indologist and philanthropist Nabanita Handique, Indian politician Robin Handique (died 2005), Indian terrorist
See also Handique Girls College, a constituent college of the University of Guwahati in Assam, India