Defries or De Fries is a surname. Notable people with the surname include:
People Colin Defries (1884–1963), English racing driver and pilot Graham Francis Defries, British lawyer Joel Defries (born 1985), British-born presenter Robert Defries (1889–1975), Canadian physician Ruth DeFries (born 1956), American environmental geographer Tony Defries (born 1943), British music manager and impresario Phil De Fries (born 1987), British mixed martial artist Heinrich de Fries (1887–1938), German architect
See also Fries (surname)