Sissako is a surname. Notable persons with the surname include:
Abderrahmane Sissako (born 1961), Mauritanian-born Malian film director and producer Abdoulaye Sissako (born 1998), French footballer Mamadou Sissako (born 1996), French footballer Moussa Sissako (born 2000), French footballer
See also Cissokho Cissoko Sissoko