Senator Clayton may refer to:
Members of the United States Senate John M. Clayton (1796–1856), U.S. Senator from Delaware from 1829 to 1836, from 1845 to 1849, and from 1853 to 1856 Joshua Clayton (1744–1798), U.S. Senator from Delaware in 1798 Powell Clayton (1833–1914), U.S. Senator from Arkansas from 1871 to 1877 Thomas Clayton (1777–1854), U.S. Senator from Delaware from 1824 to 1827 and from 1837 to 1847
United States state senate members Augustin Smith Clayton (1783–1839), Georgia State Senate John M. Clayton (Arkansas politician) (1840–1889), Arkansas State Senate Ralph R. Clayton (1922–2006), Florida State Senate William C. Clayton (1831–1915), West Virginia State Senate