Comi is a surname. Notable people with the surname include:
Anne Comi, American pediatric neurologist Antonio Comi (born 1964), Italian footballer Francesco Comi (1682–1769), Italian painter Gianmario Comi (born 1992), Italian footballer Girolamo Comi (1507–1581), Italian painter Lara Comi (born 1983), Italian politician Paul Comi (1932–2016), American actor