Shupe Run is a long 2nd order tributary to Jacobs Creek in Westmoreland County, Pennsylvania.
Course Shupe Run rises about 0.25 miles north of Mount Pleasant, Pennsylvania, and then flows south to join Jacobs Creek at Buckeye.
Watershed Shupe Run drains of area, receives about 42.5 in/year of precipitation, has a wetness index of 415.01, and is about 20% forested.
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