HS665 is a drug which acts as a potent and selective κ-opioid receptor agonist, and has analgesic effects in animal studies. HS665 is not an agonist for the μ-opioid receptor, leading to less potential for misuse.
The structure of HS665 is a close analog of an existing compound called RU-24213. RU-24213 has D2-agonist and KOR antagonist pharmacology.Fortin M, Degryse M, Petit F, Hunt PF. The dopamine D2 agonists RU 24213 and RU 24926 are also kappa-opioid receptor antagonists. Neuropharmacology. 1991 Apr;30(4):409-12. doi: 10.1016/0028-3908(91)90068-m. PMID: 1677169.
See also Substituted phenethylamine Demelverine RU-24213 Ritodrine
References
External links HS665 - Isomer Design