Giffin is a surname. Notable people with the surname include:
D. Logan Giffin (1890–1980), American lawyer and politician David Giffin (born 1973), Australian rugby player Emily Giffin (born 1972), American author Etta Josselyn Giffin (1863–1932), American librarian Fred Giffin (1920–1999), Australian weightlifter Gordon Giffin (born 1949), American diplomat Lee Giffin (born 1967), American ice hockey player Merritt Giffin (1887–1911), American athlete Michael Giffin (born 1984), Canadian football player Roger Giffin, English luthier Ron Giffin (1942–2021), Canadian lawyer and politician Simon Osborn Giffin (1870–1935), Canadian merchant and politician
See also Giffin House, a historic house in New Hampshire, US