Gaine is a surname. Notable people with the surname include:
Brian Gaine, American football executive Hugh Gaine (1726–1807), American printer
See also Explosive booster, also known as a "gaine" Gandarbha, Nepalese tribal community also known as "Gaine" Gaines (disambiguation) Gayne (disambiguation) The Brave Express Might Gaine, 1993 Japanese television series