Isaac Brown may refer to:
Isaac H. Brown (1812–1880), American sexton Issac Ryan Brown (born 2005), American actor Isaac Van Arsdale Brown (1784–1861), American educator and Presbyterian clergyman who founded the Lawrenceville School in New Jersey Isaac Brown (American football), American football player Isaac Brown (basketball) (born 1969), American basketball coach Isaac Brown (naval officer) (1817–1889), American naval officer in the US and Confederate navies Isaac Brown (Wisconsin pioneer), the 3rd mayor of Fond du Lac, Wisconsin Ike Brown (1942–2001), American baseball player Ike Brown (Canadian football) (born 1951)
See also Isaac Brown House, a single-family home in Kalamazoo, Michigan