Saints Constantine and Helena Church may refer to:

Australia Cathedral of Saints Constantine and Helene

Bulgaria Church of Sts. Constantine and Helena (Plovdiv)

Poland The Orthodox Parish of Saints Constantine and Helen in Zgorzelec

Romania Focșani Military Chapel Livedea Gospod Church

North Macedonia Church of Sts. Constantine and Helena (Skopje)

Russia Sts. Constantine and Helen Church, Novocherkassk

Serbia Church of Saints Emperor Constantine and Empress Helena

Turkey Church of Sts. Constantine and Helen (Edirne)

United States

Sts. Constantine and Helen Greek Orthodox Cathedral Saints Constantine and Helen Greek Orthodox Cathedral of the Pacific (Honolulu) Sts. Constantine and Helen Serbian Orthodox Church Sts. Constantine and Helen Chapel Mosque Maryam (former church)