Helfer (German for "helper", also "ally" or "personal assistant") is a German surname. Notable people with the surname include:
Al Helfer (1911–1975), American sportscaster Andy Helfer (born 1958), American comics writer Erwin Helfer (born 1936), American pianist Johann Wilhelm Helfer (1810–1840), Bohemian scientist Laurence Helfer (born 1965), American lawyer Monika Helfer (1947–2026), Austrian writer Ralph Helfer (born 1931), American animal behaviorist Tricia Helfer (born 1974), Canadian actress
See also Charles d'Helfer (1598–1661), French composer Helfer, rank