Line 22 may refer to:
Line 22 (Beijing Subway), rapid transit line of the Beijing Subway, under construction, in Beijing and Sanhe, China Line 22 (Guangzhou Metro), metro line of the Guangzhou Metro in Guangzhou, Guangdong province, China Line 22 (São Paulo Metro), future metro line of the São Paulo Metro in São Paulo, Brazil Line 22 (Shanghai Metro), future metro line of Shanghai Metro in Shanghai, China
See also Route 22 (disambiguation)