John Comstock may refer to:
John H. Comstock (1904–1993), American politician and attorney from Nebraska John Henry Comstock (1849–1931), American entomologist John Lee Comstock (1787–1858) American surgeon and educator John Comstock, a minor character in The Baroque Cycle novels John Comstock, the last living person removed from the stack of logs in the 1999 Aggie Bonfire collapse