Buonomo is an Italian surname. Notable people with the surname include:
Alfonso Buonomo (1829–1903), Italian composer Antonio Buonomo (1932–2025), Italian composer, solo percussionist, and music educator Jeannette Ramos Buonomo (1932–2021), Puerto Rican judge Joseph Buonomo (born 1943), American entrepreneur Brian Buonomo, Engineering Technology Educator at West Islip High School