Senator Locke may refer to:
David H. Locke (1927–2019), Massachusetts State Senate Francis Locke Jr. (1776–1823), elected as a U.S. Senator from North Carolina in 1814, but resigned before qualifying Harry M. Locke (1902–1974), Colorado State Senate James William Locke (1837–1922), Florida State Senate John Locke (Massachusetts politician) (1764–1855), Massachusetts State Senate Mamie Locke (born 1954), Virginia State Senate Matthew Locke (North Carolina politician) (1730–1801), North Carolina State Senate Matthew Fielding Locke (1824–1911), Texas State Senate Orrin Wiley Locke (1859–1951), Vermont State Senate