De Falco is a surname. Notable persons with that name include:
Andrea De Falco (born 1986), Italian footballer Giuseppe De Falco (1908–1955), Italian politician Gregorio de Falco (born 1965), Italian naval officer and politician Lawrence Michael De Falco (1915–1979), American Catholic bishop Luigi De Falco (born 1976), Italian businessman Marcel De Falco (born 1962), French footballer Michele de Falco (c. 1688–after 1732), Italian composer Rubens de Falco (1931–2008), Brazilian actor Tom DeFalco (born 1950), American comic book writer and editor Torey DeFalco (born 1997), American volleyball player
See also Falco (disambiguation) Falco (surname), a list of people with the surname Falco or Falcó