The 2021 Toronto Blue Jays season was the franchise's 45th season in Major League Baseball.

Due to the COVID-19 pandemic and associated travel restrictions, the team played their first 21 games at their spring training home of TD Ballpark in Dunedin, Florida, instead of returning to their normal home of Rogers Centre in Toronto, with the hope of moving back once Canada–U.S. travel restrictions were eased. Starting in June, the team then played 23 home games at Sahlen Field in Buffalo, New York (their home in 2020). On July 30, the Blue Jays returned to Rogers Centre for the first time since the 2019 season.

The Blue Jays finished the regular season with a 91–71 record, giving the team their best win percentage since 2015, but did not qualify for the postseason. The team finished in fourth place in the American League East, one game behind both the Boston Red Sox and New York Yankees, which secured the AL's two wild card spots.

Offseason The Toronto Blue Jays signed Robbie Ray, Tyler Chatwood, Kirby Yates, George Springer, Marcus Semien, and Joe Panik. However, Yates had a season-ending Tommy John surgery shortly before the start of the regular season, the second such surgery in his life.

Regular season

Standings American League East

American League Wild Card

Blue Jays team leaders Batting Batting average Vladimir Guerrero Jr. .311 RBIs Teoscar Hernández 116 Home runs Vladimir Guerrero Jr. 48 Runs scored 123 Stolen bases Bo Bichette 25Pitching Wins Hyun-jin Ryu 14 ERA Robbie Ray 2.84 WHIP 1.04 Strikeouts 248 Saves Jordan Romano 23

Minimum 3.1 plate appearances per team games played AVG qualified batters: Bichette, Grichuk, Guerrero Jr., Gurriel Jr., Hernández, Semien

Minimum 1 inning pitched per team games played ERA & WHIP qualified pitchers: Ray, Ryu

Records vs opponents

Record Games Left Opponent Home Road Total Home Road Total AL East Baltimore Orioles 8–2 6–3 14–5 – – – Boston Red Sox 4–5 5–5 9–10 – – – New York Yankees 3–6 8–2 11–8 – – – Tampa Bay Rays 4–6 4–5 8–11 – – –Totals 19–19 23–15 42–34 – – – AL Central Chicago White Sox 2–2 1–2 3–4 – – – Cleveland Indians 3–1 2–1 5–2 – – – Detroit Tigers 1–2 2–1 3–3 – – – Kansas City Royals 3–0 1–3 4–3 – – – Minnesota Twins 2–1 2–2 4–3 – – –Totals 11–6 8–9 19–15 – – – AL West Houston Astros 1–2 1–2 2–4 – – – Los Angeles Angels 1–3 2–1 3–4 – – – Oakland Athletics 3–0 2–2 5–2 – – – Seattle Mariners 1–2 1–2 2–4 – – – Texas Rangers 3–0 1–2 4–2 – – –Totals 9–7 7–9 16–16 – – – National League Atlanta Braves 3–0 3–0 6–0 – – – Miami Marlins 2–0 2–0 4–0 – – – New York Mets – 1–2 1–2 – – – Philadelphia Phillies 2–1 – 2–1 – – – Washington Nationals 1–1 0–2 1–3 – – –Totals 8–2 6–4 14–6 – – – Grand Totals 47–34 44–37 91–71 – – – Month Games Won Lost Pct. April 24 12 12 May 28 15 13 June 26 14 12 July 23 12 11 August 30 16 14 September 28 19 9 October 3 3 0 Totals 162 91 71

2021 draft The 2021 Major League Baseball draft began on July 11. The draft was shortened to 20 rounds for the 2021 season due to the ongoing COVID-19 pandemic. The Blue Jays forfeited their second round selection due to signing George Springer during the offseason. Round Pick Player Position College/School Nationality Signed 1 19 Gunnar Hoglund RHP Ole Miss July 16 3 91 Ricky Tiedemann LHP Golden West July 21 4 121 Chad Dallas RHP Tennessee July 17 5 152 Irv Carter RHP Calvary Christian Academy July 19 6 182 Hayden Juenger RHP Missouri State July 21 7 212 Jaden Rudd OF A. Crawford Mosley High School July 21 8 242 Hunter Gregory RHP Old Dominion July 21 9 272 Conor Larkin RHP Penn State July 21 10 302 Connor Cooke RHP Louisiana-Lafayette July 21

Game log Legend Blue Jays win Blue Jays loss Game postponed

|- style="background:#bfb;" | 1 || April 1 || @ Yankees || 3–2 || Romano (1–0) || Nelson (0–1) || Merryweather (1) || 10,850 || 1–0 || — |- style="background:#fbb;" | 2 || April 3 || @ Yankees || 3–5 || Loáisiga (1–0) || Stripling (0–1) || Green (1) || 10,107 || 1–1 || 1 |- style="background:#bfb;" | 3 || April 4 || @ Yankees || 3–1 || Borucki (1–0) || Germán (0–1) || Merryweather (2) || 10,066 || 2–1 || 1 |- style="background:#bfb;" | 4 || April 5 || @ Rangers || 6–2 || Matz (1–0) || Foltynewicz (0–1) || — || 38,258 || 3–1 || — |- style="background:#fbb;" | 5 || April 6 || @ Rangers || 4–7 || Dunning (1–0) || Roark (0–1) || Kennedy (1) || 18,585 || 3–2 || — |- style="background:#fbb;" | 6 || April 7 || @ Rangers || 1–2 || Gibson (1–0) || Ryu (0–1) || Kennedy (2) || 16,876 || 3–3 || 1 |- style="background:#fbb;" | 7 || April 8 || Angels || 5–7 || Guerra (2–0) || Borucki (1–1) || Iglesias (2) || 1,348 || 3–4 || 1 |- style="background:#fbb;" | 8 || April 9 || Angels || 1–7 || Heaney (1–1) || Zeuch (0–1) || — || 1,523 || 3–5 || 1½ |- style="background:#bfb;" | 9 || April 10 || Angels || 15–1 || Matz (2–0) || Quintana (0–1) || Milone (1) || 1,292 || 4–5 || 1½ |- style="background:#bbb;" | – || April 11 || Angels || colspan=7 | Postponed (Rain, Makeup August 10) |- style="background: |- style="background:#fbb;" | 10 || April 12 || Yankees || 1–3 || Cole (2–0) || Ray (0–1) || Chapman (1) || 1,576 || 4–6 || 2½ |- style="background:#bfb;" | 11 || April 13 || Yankees || 7–3 || Ryu (1–1) || Taillon (0–1) || — || 1,550 || 5–6 || 2½ |- style="background:#bfb;" | 12 || April 14 || Yankees || 5–4 || Dolis (1–0) || Green (0–2) || — || 1,613 || 6–6 || 3 |- style="background:#fbb;" | 13 || April 15 || @ Royals || 5–7 || Junis (1–0) || Kay (0–1) || Barlow (1) || 6,266 || 6–7 || 3 |- style="background:#bbb;" | — || April 16 || @ Royals || colspan=8| Postponed (Rain, Makeup: April 17) |- style="background:#bfb;" | 14 || April 17 || @ Royals || 5–1 || Matz (3–0) || Minor (1–1) || — || 9,048 || 7–7 || |- style="background:#fbb;" | 15 || April 17 || @ Royals || 2–3 || Holland (2–1) || Payamps (0–1) || — || 8,950 || 7–8 || 3½ |- style="background:#fbb;" | 16 || April 18 || @ Royals || 0–2 || Zimmer (1–0) || Zeuch (0–2) || Holland (2) || 9,042 || 7–9 || 3 |- style="background:#fbb;" | 17 || April 20 || @ Red Sox || 2–4 || Rodríguez (3–0) || Ryu (1–2) || Barnes (3) || 4,728 || 7–10 || 4½ |- style="background:#bfb;" | 18 || April 21 || @ Red Sox || 6–3 || Borucki (2–1) || Richards (0–2) || Castro (1) || 4,661 || 8–10 || 3½ |- style="background:#bfb;" | 19 || April 23 || @ Rays || 5–3 || Matz (4–0) || Glasnow (2–1) || Dolis (1) || 5,564 || 9–10 || 3 |- style="background:#fbb;" | 20 || April 24 || @ Rays || 3–5 || Thompson (2–1) || Romano (1–1) || Kittredge (1) || 6,688 || 9–11 || 3 |- style="background:#bfb;" | 21 || April 25 || @ Rays || 1–0 || Mayza (1–0) || Fleming (1–2) || Dolis (2) || 6,372 || 10–11 || 3 |- style="background:#bfb;" | 22 || April 27 || Nationals || 9–5 || Milone (1–0) || Scherzer (1–2) || — || 1,471 || 11–11 || 3 |- style="background:#fbb;" | 23 || April 28 || Nationals || 2–8 || Fedde (2–2) || Matz (4–1) || — || 1,274 || 11–12 || 4 |- style="background:#bfb;" | 24 || April 30 || Braves || 13–5 || Ray (1–1) || Smyly (0–2) || — || 1,629 || 12–12 || 3½

|- style="background:#bfb;" | 25 || May 1 || Braves || 6–5 || Romano (2–1) || Jones (0–2) || — || 1,634 || 13–12 || 2½ |- style="background:#bfb;" | 26 || May 2 || Braves || 7–2 || Borucki (3–1) || Anderson (2–1) || Dolis (3) || 1,554 || 14–12 || 1½ |- style="background:#fbb;" | 27 || May 3 || @ Athletics || 4–5 || Montas (3–2) || Matz (4–2) || Diekman (3) || 2,944 || 14–13 || 2 |- style="background:#fbb;" | 28 || May 4 || @ Athletics || 1–4 || Irvin (3–3) || Kay (0–2) || Petit (1) || 2,970 || 14–14 || 3 |- style="background:#bfb;" | 29 || May 5 || @ Athletics || 9–4 || Romano (3–1) || Trivino (1–1) || — || 2,893 || 15–14 || 2 |- style="background:#bfb;" | 30 || May 6 || @ Athletics || 10–4 || Ryu (2–2) || Fiers (0–2) || — || 3,611 || 16–14 || 2 |- style="background:#fbb;" | 31 || May 7 || @ Astros || 4–10 || Urquidy (3–2) || Stripling (0–2) || — || 25,410 || 16–15 || 3 |- style="background:#bfb;" | 32 || May 8 || @ Astros || 8–4 || Matz (5–2) || Javier (3–1) || — || 25,794 || 17–15 || 3 |- style="background:#fbb;" | 33 || May 9 || @ Astros || 4–7 || Abreu (2–1) || Pearson (0–1) || Pressly (6) || 24,355 || 17–16 || 4 |- style="background:#bfb;" | 34 || May 11 || @ Braves || 5–3 || Thornton (1–0) || Minter (1–1) || Romano (1) || 21,688 || 18–16 || 2½ |- style="background:#bfb;" | 35 || May 12 || @ Braves || 4–1 || Ryu (3–2) || Jackson (1–1) || Cole (1) || 21,171 || 19–16 || 1½ |- style="background:#bfb;" | 36 || May 13 || @ Braves || 8–4 || Bergen (1–0) || Smith (0–3) || — || 21,653 || 20–16 || 1½ |- style="background:#fbb;" | 37 || May 14 || Phillies || 1–5 || Brogdon (4–1) || Thornton (1–1) || — || 1,171 || 20–17 || 2½ |- style="background:#bfb;" | 38 || May 15 || Phillies || 4–0 || Bergen (2–0) || Nola (3–3) || — || 1,397 || 21–17 || 2½ |- style="background:#bfb;" | 39 || May 16 || Phillies || 10–8 || Ray (2–1) || Anderson (2–4) || — || 1,107 || 22–17 || 1½ |- style="background:#bfb;" | 40 || May 18 || Red Sox || 8–0 || Ryu (4–2) || Rodríguez (5–2) || — || 1,566 || 23–17 || ½ |- style="background:#fbb;" | 41 || May 19 || Red Sox || 3–7 || Richards (4–2) || Stripling (0–3) || — || 1,581 || 23–18 || 1½ |- style="background:#fbb;" | 42 || May 20 || Red Sox || 7–8 || Valdéz (2–0) || Dolis (1–1) || Barnes (10) || 1,562 || 23–19 || 2½ |- style="background:#fbb;" | 43 || May 21 || Rays || 7–9 || Castillo (1–2) || Beasley (0–1) || — || 1,437 || 23–20 || 3½ |- style="background:#fbb;" | 44 || May 22 || Rays || 1–3 || Kittredge (5–0) || Castro (0–1) || Castillo (8) || 1,514 || 23–21 || 4½ |- style="background:#fbb;" | 45 || May 23 || Rays || 4–6 || Fleming (4–3) || Chatwood (0–1) || Feyereisen (1) || 1,496 || 23–22 || 4½ |- style="background:#fbb;" | 46 || May 24 || Rays || 8–14 || Springs (4–1) || Payamps (0–2) || — || 1,641 || 23–23 || 5½ |- style="background:#bfb;" | 47 || May 25 || @ Yankees || 6–2 || Matz (6–2) || Kluber (4–3) || — || 12,025 || 24–23 || 4½ |- style="background:#bbb;" | — || May 26 || @ Yankees || colspan=7 | Postponed (Rain, Makeup May 27) |- style="background:#bfb;" | 48 || May 27 || @ Yankees || 2–0 || Manoah (1–0) || Germán (4–3) || Romano (2) || N/A || 25–23 || |- style="background:#fbb;" | 49 || May 27 || @ Yankees || 3–5 || Loáisiga (4–2) || Ray (2–2) || Green (2) || 14,056 || 25–24 || 5½ |- style="background:#bfb;" | 50 || May 28 || @ Indians || 11–2 || Ryu (5–2) || Morgan (0–1) || — || 9,198 || 26–24 || 5 |- style="background:#bbb;" | — || May 29 || @ Indians || colspan=7 | Postponed (Rain, Makeup May 30) |- style="background:#bfb;" | 51 || May 30 || @ Indians || 4–1 || Stripling (1–3) || Civale (7–2) || Romano (3) || N/A || 27–24 || 5½ |- style="background:#fbb;" | 52 || May 30 || @ Indians || 5–6 || Clase (3–2) || Chatwood (0–2) || — || 11,690 || 27–25 || 6

|- style="background:#bfb;" | 53 || June 1 || Marlins || 5–1 || Ray (3–2) || Alcántara (2–5) || — || 5,321 || 28–25 || 5½ |- style="background:#bfb;" | 54 || June 2 || Marlins || 6–5 || Castro (1–1) || García (3–4) || — || 5,385 || 29–25 || 4½ |- style="background:#fbb;" | 55 || June 4 || Astros || 1–13 || Greinke (6–2) || Ryu (5–3) || — || 5,510 || 29–26 || 5 |- style="background:#bfb;" | 56 || June 5 || Astros || 6–2 || Stripling (2–3) || Urquidy (4–3) || — || 5,327 || 30–26 || 5 |- style="background:#fbb;" | 57 || June 6 || Astros || 3–6 || García (5–3) || Matz (6–3) || Pressly (9) || 5,404 || 30–27 || 6 |- style="background:#fbb;" | 58 || June 8 || @ White Sox || 1–6 || Crochet (2–2) || Thornton (1–2) || — || 12,761 || 30–28 || 7 |- style="background:#bfb;" | 59 || June 9 || @ White Sox || 6–2 || Chatwood (1–2) || Bummer (0–4) || — || 14,438 || 31–28 || 6 |- style="background:#fbb;" | 60 || June 10 || @ White Sox || 2–5 || Keuchel (5–1) || Ryu (5–4) || Hendriks (16) || 16,903 || 31-29 || 6½ |- style="background:#fbb;" | 61 || June 11 || @ Red Sox || 5–6 || Whitlock (2–1) || Dolis (1–2) || — || 25,257 || 31–30 || 7½ |- style="background:#bfb;"