Espínola is Spanish surname, which may refer to:
Arnaldo Espínola, Paraguayan footballer Carlos Espínola (sailor), Argentine windsurfer and politician Carlos González Espínola, Paraguayan footballer Darío Espínola, Argentine footballer Ernesto Espinola, Paraguayan chess player Juan Espínola (footballer), Paraguayan footballer Lourdes Espinola, Paraguayan poet, diplomat, cultural promoter María Espínola, Argentine windsurfer Néstor Espínola, Argentine footballer Víctor Espínola, Paraguayan multi-instrumentalist and singer