Shyu is the Gwoyeu Romatzyh romanization of the Chinese surname Xú (). People with this surname include:
Heidi Shyu (; born 1953), American engineer and Department of Defense official Shyu Jong-shyong (; born 1957), Taiwanese politician, Deputy Secretary-General of the Executive Yuan Shyu Jyuo-min (; ), Taiwanese engineer and politician, Minister of Science and Technology Jen Shyu (; born 1978), American jazz musician Mei-Ling Shyu, computer scientist