Senator Sprague may refer to:
Members of the United States Senate Peleg Sprague (Maine politician) (1793–1880), U.S. Senator from Maine from 1829 to 1835 William Sprague III (1799–1856), U.S. Senator from Rhode Island from 1842 to 1844 William Sprague IV (1830–1915), U.S. Senator from Rhode Island from 1863 to 1875
United States state senate members Charles F. Sprague (1857–1902), Massachusetts State Senate E. Carleton Sprague (1822–1895), New York State Senate Frederick Sprague (fl. 1840s–1850s), Wisconsin State Senate Henry H. Sprague (1841–1920), Massachusetts State Senate Jo Ann Sprague (born 1931), Massachusetts State Senate Nathan Turner Sprague (1828–1903), Vermont State Senate Royal Sprague (1814–1872), California State Senate William P. Sprague (1827–1899), Ohio State Senate