Khalis () is a given name and surname. Notable people with the name include:
Khalis Bayyan or Ronald Bell (1951–2020), American singer-songwriter Mehdi Khalis (born 1989), Moroccan footballer Mohammad Yunus Khalis (c. 1919–2006), Afghan mujahideen commander Khalis (comics), fictional character from DC Comics
See also Kalis (surname)