Isham is a masculine given name which may refer to:
Isham Hardy (1899–1983), American football player Isham G. Harris (1818–1897), American politician, governor of Tennessee and senator Isham Jones (1894–1956), American bandleader, saxophonist, bassist and songwriter Isham F. Norris (1851–1928), African-American businessman and politician Isham Randolph (1684–1742), American planter, merchant, public official and shipmaster, maternal grandfather of Thomas Jefferson Isham Reavis (1836–1914), American jurist, associate justice of the Supreme Court of Arizona Territory Isham Shahruddin (born 1966), Malaysian former footballer Isham Singh, Indian politician