Penno is a surname or, more rarely, a given name that may refer to:
Surname Enno Penno (1930–2016), Estonian politician Gino Penno (1920–1998), Italian tenor Rudolf Penno (1896–1951), Estonian politician Sebastian Penno (born 1990), German politician William A. Penno, Jr. (1843–1929), American banjo player, composer, music teacher