Brignoni is an Italian surname. Notable people with the surname include:
Jonas Brignoni Dos Santos (born 1983), Brazilian football player Luis Brignoni (born 1953), Puerto Rican basketball player Nicolas Brignoni (born 197), Uruguayan rugby player Serge Brignoni (1903–2002), Swiss painter and sculptor
Other United States v. Brignoni-Ponce, a 1975 court case